Synthetic E.Coli Toggle Switch equations using JOde
Eduardo Sontag's Gardner/Cantor/Collins Synthetic E.Coli Toggle Switch equations using JOde, for classroom use.
You should look at
this paper first.
Click at a about 10 random places in the screen, and see what the
trajectories look like.
should see a bi-stable phase-plane (two stable states). Print.
"Clear all" so that the screen looks clean.
Change b and g to equal 2, instead of 10. Submit all. Redo part 1. Is the system
bistable now? Print.
Clear all. Now, still with b=g=2, try a1=a2=10. Submit all. Repeat. What
happens? (This is a little tricky; consider modifying the ranges of u and v.)
Explain how the fact that we needed to use larger b's and g's in order to get
bistability, for a1=a2=1, but we could get away with smaller b's and g's when
a1=a2=10 matches what the authors of the paper show in Figure 2(d).
Instructions on using the JOde Applet
Using the applet written by: Marek Rychlik